Serum Thrombomodulin after Lung Resection
نویسندگان
چکیده
135 Received June 1, 2012; accepted September 3, 2012. Published online September 14, 2012; doi: 10.1620/tjem.228.135. Correspondence: Sumiko Maeda, M.D., Ph.D., Department of Thoracic Surgery, Tohoku University Hospital, 4-1 Seiryomachi, Aobaku, Sendai, Miyagi 980-8575, Japan. e-mail: [email protected] *Present address: Department of Thoracic Surgery, Tohoku University Hospital, 4-1 Seiryomachi, Aobaku, Sendai, Miyagi 980-8575, Japan. Serum Thrombomodulin as a Newly Identified Biomarker for Postoperative Lung Injury: A Prospective Observational Study
منابع مشابه
Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis.
OBJECTIVE We sought to develop a murine model to examine the antithrombotic and antiinflammatory functions of human thrombomodulin in vivo. METHODS AND RESULTS Knock-in mice that express human thrombomodulin from the murine thrombomodulin gene locus were generated. Compared with wild-type mice, human thrombomodulin knock-in mice exhibited decreased protein C activation in the aorta (P<0.01) a...
متن کاملA role for thrombomodulin in the pathogenesis of thrombin-induced thromboembolism in mice.
The antithrombotic action of thrombomodulin was studied in mice. Rat and mouse thrombomodulin were isolated from lung acetone powders, and anti-rat thrombomodulin antibodies were prepared in rabbits. The antibodies neutralized both mouse (Kd approximately 150 nM) and rat thrombomodulin (Kd approximately 50 nM). A role for thrombomodulin in vivo was shown in mice injected intravenously (IV) with...
متن کاملChanges in Blood Gases and Hemodynamic Parameters in Patients Undergoing Lung Resection Surgery and Its Clinical Implications
Introduction: Lung resection surgery is a challenge to thoracic surgeons. Outcome of surgery depends on patients’ tolerance to reduced lung volume and hemodynamic alterations. The present study aimed to investigate the changes in blood gases and hemodynamic parameters in patients undergoing lung resection surgery and the associated clinical implications. Materials and methods: This study includ...
متن کاملAnalysis of the Results of Pulmonary Resection by Minimally Invasive Thoracoscopy for the Surgical Treatment of Lung Cancer
Introduction: Lung cancer is the disease of modern era, and the rate of lung cancer mortality is three times as high as that for prostate cancer and twice as high as the rate for breast cancer. We aimed to analyze the results of pulmonary resection in patients with NSCLC by minimally invasive thoracoscopy. Materials and Methods: We studied 10 patients with NSCLC scheduled for surgical resectio...
متن کاملDetected troponin elevation is associated with high early mortality after lung resection for cancer
BACKGROUND Myocardial infarction can be difficult to diagnose after lung surgery. As recent diagnostic criteria emphasize serum cardiac markers (in particular serum troponin) we set out to evaluate its clinical utility and to establish the long term prognostic impact of detected abnormal postoperative troponin levels after lung resection. METHODS We studied a historic cohort of patients with ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012